Healthcare

Lactam technology has a range of anti-biofilm applications across the dental, medical and veterinary healthcare environments.

Healthcare

Lactam technology has a range of anti-biofilm applications across the dental, medical and veterinary healthcare environments.

Dental

Dental plaque is an example of a typical biofilm composed of a complex microbial community.  Plaque is the contributing agent for major dental diseases such as dental caries and periodontal disease.  The clinical picture of these diseases is a net result of the communication between the pathogenic dental plaque biofilm and the host tissue response.  In the healthy state, both plaque biofilm and adjacent tissues maintain a delicate balance, however, changes occur during the disease process that transform this ‘healthy’ dental plaque into a ‘pathogenic’ biofilm.

Biofilm formation is also a problem in certain pieces of professional dentistry equipment.  Dental chair units (DCUs) use water to cool and irrigate instruments and tooth surfaces, and provide rinsewater during dental treatment. A network of interconnected plastic dental unit waterlines (DUWLs) supply water to these instruments. DUWLs are highly prone to microbial biofilm contamination and, as a consequence, DUWL output water invariably becomes contaminated by high densities of microorganisms, Lactam technology formulations are being developed to address this market for cleaning DUWL systems.

Penrhos are in licence discussions with potential partners in the US.

Dental

Dental plaque is an example of a typical biofilm composed of a complex microbial community.  Plaque is the contributing agent for major dental diseases such as dental caries and periodontal disease.  The clinical picture of these diseases is a net result of the communication between the pathogenic dental plaque biofilm and the host tissue response.  In the healthy state, both plaque biofilm and adjacent tissues maintain a delicate balance, however, changes occur during the disease process that transform this ‘healthy’ dental plaque into a ‘pathogenic’ biofilm.

Biofilm formation is also a problem in certain pieces of professional dentistry equipment.  Dental chair units (DCUs) use water to cool and irrigate instruments and tooth surfaces, and provide rinsewater during dental treatment. A network of interconnected plastic dental unit waterlines (DUWLs) supply water to these instruments. DUWLs are highly prone to microbial biofilm contamination and, as a consequence, DUWL output water invariably becomes contaminated by high densities of microorganisms, Lactam technology formulations are being developed to address this market for cleaning DUWL systems.

Penrhos are in licence discussions with potential partners in the US.

Medical

Biofilm formation by pathogenic microbes that protect pathogens from host immune defense and antimicrobial agents is a leading cause of healthcare associated infections (HAI’s).

Urinary tract infection is one of the most common HAI’s.  In-dwelling urinary catheters are typically in place for 4-12 weeks and are therefore a fertile breeding ground for bacteria to colonise and to form biofilms. Between 15-25% of hospitalised patients receive urinary catheters during their stay, so the healthcare impacts of these infections are considerable.

Penrhos Bio is working with partners to assess the efficacy of anti-biofilm lactam treatment on urinary catheters and other non-blood contact applications in healthcare that are particularly susceptible to biofilm formation.

Medical

Biofilm formation by pathogenic microbes that protect pathogens from host immune defense and antimicrobial agents is a leading cause of healthcare associated infections (HAI’s).

Urinary tract infection is one of the most common HAI’s.  In-dwelling urinary catheters are typically in place for 4-12 weeks and are therefore a fertile breeding ground for bacteria to colonise and to form biofilms. Between 15-25% of hospitalised patients receive urinary catheters during their stay, so the healthcare impacts of these infections are considerable.

Penrhos Bio is working with partners to assess the efficacy of anti-biofilm lactam treatment on urinary catheters and other non-blood contact applications in healthcare that are particularly susceptible to biofilm formation.

Veterinary

A vast array of pathogenic microorganisms frequently comes into contact with various surfaces in animal habitats. This poses a serious challenge to the human food industry through contamination and spoilage of food, but also to the health and wellbeing of the animals themselves. In addition, many of the pathogens are zoonotic and there is a threat to the handlers and owners of these animals.

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Veterinary

A vast array of pathogenic microorganisms frequently comes into contact with various surfaces in animal habitats. This poses a serious challenge to the human food industry through contamination and spoilage of food, but also to the health and wellbeing of the animals themselves. In addition, many of the pathogens are zoonotic and there is a threat to the handlers and owners of these animals.

Veterinary

A vast array of pathogenic microorganisms frequently comes into contact with various surfaces in animal habitats. This poses a serious challenge to the human food industry through contamination and spoilage of food, but also to the health and wellbeing of the animals themselves. In addition, many of the pathogens are zoonotic and there is a threat to the handlers and owners of these animals.

The scale of the industry, and importance of the supply of food, means that there has been extensive veterinary use of antimicrobial agents to treat livestock, a factor considered to have contributed significantly to the development of antimicrobial resistance. In addition, on farms, there is a wide use of cleaning agents and disinfectants that risk environmental contamination and entry to the food chain.

The formation of biofilms in these contexts has made treatment and prevention of disease more challenging – especially in large scale animal production environments requiring use of later generation antibiotics at higher concentrations and a greater cost. For example – mastitis in dairy cattle which is very difficult to treat due to biofilm formation.

Penrhos Bio is working with partners to assess the veterinary market opportunity for lactam technology.

The scale of the industry, and importance of the supply of food, means that there has been extensive veterinary use of antimicrobial agents to treat livestock, a factor considered to have contributed significantly to the development of antimicrobial resistance. In addition, on farms, there is a wide use of cleaning agents and disinfectants that risk environmental contamination and entry to the food chain.

The formation of biofilms in these contexts has made treatment and prevention of disease more challenging – especially in large scale animal production environments requiring use of later generation antibiotics at higher concentrations and a greater cost. For example – mastitis in dairy cattle which is very difficult to treat due to biofilm formation.

Penrhos Bio is working with partners to assess the veterinary market opportunity for lactam technology.